When the Cowboys (8-3) host the Colts (4-7-1) in the penultimate game of NFL Week 13 on "Sunday Night Football" (8:20 p.m. ET, NBC), they will be looking to keep rolling at home.Dallas is coming off a long week, having played and beaten the Giants on traditional Thanksgiving Thursday. Indianapolis, meanwhile, played and lost to Pittsburgh at home on Monday night.The Cowboys have built on their 2021 momentum and doing it with the defense and running game with Dak Prescott not needing to do as much coming back from his latest injury. The Colts got a mini spark from interim coach Jeff Saturday, but the i sues around Matt Miami Hurricanes Jersey Ryan have resurfaced to make them offensively inept.Here's everything to know about betting on Cowboys vs. Colts in Week 13, including updated odds, trends and our prediction for "Sunday Night Football."NFL WEEK 13 PICKS: | Spread: Cowboys by 10.5Over/under: 44.5Moneyline:Colts +400, Cowboys -550The Cowboys have been circling around double-digit favorites and got there late in the week, getting an extra point in their favor. The Colts come limping in and fading for a prime-time challenge.( )Cowboys vs. Colts all-time seriesSurprisingly, the teams have played only 17 times Dewan Hernandez Jersey . The Cowboys have won 10 of the meetings. The Colts shut out the Cowboys 23-0 in the last matchup in 2018. Before then the Cowboys won the previous three games going back to '06.Three trends to knowBettors are split 50-50 on whether the Cowboys will handle the huge number or the Colts will rebound to play well in prime time this time.Bettors are leaning hard toward the over when Michael Irvin Jersey regarding the total, locking in at a whopping 62 percent.The Colts are 5-7 against the spread this season and only three games have gone over. The Cowboys are 7-4 ATS with four games going over.Three things to watchThe Cowboys' running gameThe Colts' run defense isn't good when linebacker Shaquille Leonard isn't part of the defense. They gave up 172 yards rushing to the Steelers last week. The Cowboys just dumped 169 on the Giants with Ezekiel Elliott, Tony Pollard and more.The Colts' running gameThe Cowboys just shut down Saquon Barkley, holding him to 39 yards on 11 carries. The Steelers won by holding Jonathan Taylor in check with 86 yards on 20 carries. Taylor must explode in this matchup to give the Colts any chance with Ryan.Saturday on MondayAfter winning against the Raiders and pushing the Eagles, the Colts unraveled against the Steelers with Saturday having his first game management i sues as their head coach. HIs team will face Rodney Miller Jr. Jersey a hostile environment against a mighty well-coached opponent. He will need to dig deep with motivation and scheming for any upset Anthony Lawrence II Jersey potential.Stat that matters43 vs. 45. The first number is how many sacks the Colts have allowed this season, worst in the NFL. The second number is how many sacks the Cowboys' defense has, led by Micah Parsons, No. 1 in the NFL. Nothing needs to give here. Dallas should dominate up front with great pre sure on Ryan. The Cowboys will grind offensively with a good mix of running and intermediate pa sing from Prescott. They will be fine racking up more Brett Maher field goals to pad the lead. Ryan will be under siege once Taylor is contained and also will be hurt by negative game script.Cowboys 30, Colts 14