Baseball is back. After just 60 games last year, Major League Baseball returned to its glorious, full 162-game schedule for the 2021 season. There's already plenty to discu s; we had , as a St. Louis Cardinal, Nicholas Castellanos' fiery start to the season ( ) and the start of . And of course, in typical baseball fashion, we've already witne sed a few peculiar happenings, like a and that turned two-run home run into a one-run single.As for the purpose of this specific column, we're going to be taking a look at the winners and losers after each weekend of action this season. Here are the big winners and losers from MLB's first weekend of the 2021 season: of the Baltimore Orioles returned to the diamond on Opening Day following a year-long absence from the sport. He mi sed the entire 2020 season after being diagnosed with Stage 3 colon cancer last year. It was his first regular-season profe sional game since Sept. 29, 2019. Mancini, 29, and . In the Orioles season-opening series sweep against the at Fenway Park, Mancini played first base in all three games and drove in Kevin Byard Jersey three runs in his return to baseball.Mancini was drafted by the Orioles in the eighth round of the 2013 MLB Draft out of Notre Dame. He finished third behind and for American League Rookie of the Year in 2017. Mancini posted career-bests in 2019 with 35 home runs, 97 RBI, 38 doubles, 175 hits and 106 runs scored. Trey deserves all of this. Baltimore Orioles (@Orioles) To return to baseball after any period of time away from the game is impre sive, but for Mancini to beat cancer and return to the big leagues is truly inspiring. Not only that, but Mancini has taken on the role of a spokesperson and advocate for colon cancer awarene s. He currently serves on the Colorectal Cancer Harold Landry Jersey "Never Too Young" advisory board, which advocates for all young onset patients and survivors.Mancini's return was part of a memorable opening weekend for the O's in Boston. Baltimore outscored Boston 18-5 over three games and left town after an emphatic 11-3 Sunday win. Not a bad start for a squad that won just 54 games in the last full MLB season.The New York Mets and were the in the 2021 regular season. With multiple positive cases within the Nationals team, their Opening Day matchup on Thursday and then, soon after, their entire three-game series was postponed. It goes without saying that player and staff safety is still of utmost importance, and hopefully, with the , this can be resolved and prevented for future clubs. But, for the sake of players excited to return to play and fans excited to witne s the games, it's a real bummer. : vs. .With the postponement, that left MLB fans without a single primetime Thursday night game for Opening Day. It's not what you want when the league is desperate to grow and add new fans. Also Tennessee Titans Jersey still to come with the Mets 2021 season opener was the highly anticipated debut of the club's new franchise shortstop, . The Mets and Lindor agreed to a just before Opening Day. For the Nationals, still to come is some version of a celebration for their 2019 World Series championship. Since they took home the Commi sioner's Trophy, they haven't been able to allow fans at Nationals Park.As of now, the Mets are scheduled to face the for a three-game series in Philadelphia beginning on Monday. The Mets have not had any COVID-related i sues and seem likely to play the series. The Los Angeles Angels have a lot to prove this season. Entering the 2021 MLB season, . The biggest X factors for the Angels include the performances of their pitching staff and the bottom half of their lineup. During this weekend's series against the , the Angels showed some promise in both departments. Reiterating that I know it's incredibly early, but things could be looking up for the Anaheim ball club as the Halos try to end their six-year postseason drought.First things first, in two of their wins this weekend, the Angels produced eighth-inning comeback rallies *and* their bullpen quietly closed out the games. That's basically an unheard scenario if we're thinking back to the Angels team from last year. Now, to take a quick look at the Angels lineup (one, that in my opinion has potential be among the best in baseball) so far:2BDHCF3BLF1BSSCRFThat, right there, is a solid lineup. One, that if consistently performs, can certainly pose a threat in the American League West. . Sure, there are durability concerns with both Pujols and Ohtani, but this past weekend, things looked pretty good. In the first of a pair of comebacks, Mike Trout knocked an eighth-inning single to drive in David Fletcher and tie the game. Then, Ohtani scored the go-ahead run on Albert Pujols' groundout. Justin Upton drew an 11-pitch walk to load the bases for Pujols.The following day, Upton was clutch again, delivering the go-ahead home run. Prior to Upton's blast, Angels first baseman had hit the game-tying triple to score third baseman Anthony Rendon.Then there were the various pitching performances from this Angels club this weekend, each showing some upside. Rookie Dennis Kelly Jersey right-hander made his MLB debut and threw two scorele s innings of relief. Rodriguez struck out three batters and allowed two hits and one walk in the outing. Starter -- who L.A. acquired in a trade with the -- recorded seven strikeouts over six innings in his season debut. Cobb appeared to have good command of his fastball, but it was his curve that gave him a little bit of trouble. also recorded a solid start in his opener where he allowed three runs on six hits and a walk while striking out six over six innings and reliever earned his first save of the season. "To come together as quickly as we have is really a testament to the players, the veteran players on this team," Angels manager Joe Maddon said after the team's solid start. "I know you see a difference with this group over the last couple years just based on the veterans and more cohesivene s of the group right now."The Angels were already a winner of the weekend .Since the signed third baseman to a four-year deal worth $92 million, things haven't gone as expected. Donaldson was coming off a bounce-back season for the Braves when he signed, but in 2020, he regre sed and battled multiple injuries. He played just 28 games (81 at-bats) for Minnesota and hit .222/.373/.469 (131 OPS+) with six home runs. His last regular season game was on Sept. 25 and a calf injury kept him off the Twins' 2020 American League Wild Card roster. Then on Opening Day 2021, the veteran suffered a hamstring injury while rounding first base after his first at-bat of the season, which then .It's obviously still very early in the season, but no injury is good, and another injury-related setback could raise concerns about Donaldson's Jeffery Simmons Jersey age (35-years-old) and the po sibility that a decline is beginning to set in. For now, the Twins appear to be playing it safe with Donaldson